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Author response: The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

Year: 2025

Type: peer-review

Abstract: Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.

Source: eLife

DOI: 10.7554/elife.96743.3.sa2

Authors: Elise S Bruguera, Jacob P Mahoney, William I Weis

Institutions: Stanford University, Stanford Medicine

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W4405987273

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