Value of dynamic contrast-enhanced magnetic resonance imaging quantitative parameters in evaluating the efficacy of neoadjuvant chemoradiotherapy for cervical cancer
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: this study focused on evaluating the effectiveness of dynamic contrastenhanced magnetic resonance imaging (DCE-MRI) in patients with cervical cancer (CC) undergoing neoadjuvant chemotherapy and radiation therapy.Materials and Methods: a total of 58 CC patients were included, undergoing examination through DCE-MRI scans.Subsequently, all cases were divided into two groups: the chemotherapy-effective group (32 cases) including complete response (CR) and partial response (PR), and the chemotherapy-ineffective group (26 cases) including stable disease (SD) and disease progression (PD).Results: after treatment, the average maximum diameter of tumors in the chemotherapy and radiation therapy failure group was 4.38 ± 1.23 cm, drastically larger than the 2.51±0.64cm in the chemotherapy and radiation therapy response group (P < 0.05).Before treatment, the K trans of the chemotherapy and radiation therapy response group was superior to that of the failure group, while Ve was inferior to the latter (P < 0.05).After treatment, the K trans of the chemotherapy and radiation therapy response group decreased, showing a more drastic reduction compared to the failure group (P < 0.05).The K trans of the chemotherapy and radiation therapy response group was drastically inferior to that of the failure group, with statistical significance (P<0.05).The ΔK trans % in the chemotherapy and radiation therapy response group was negative, inferior to pre-treatment values.In contrast, the ΔK trans % in the chemotherapy and radiation therapy failure group was positive, superior to pre-treatment values (P < 0.05).Conclusion: DCE-MRI demonstrates excellent scanning performance for CC, accurately monitoring the blood flow signals of CC tumors.K trans , Ve, and ΔK trans have high predictive value in neoadjuvant chemotherapy and radiation therapy.
Authors: M. Yi, R. Hong, Zh. Zhang, Z. Xiong, J. Ran
Institutions: Chongqing University, Air Force Medical University
Language: English
Topic: MRI in cancer diagnosis
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405994585