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Rare Cardiotoxicity in a Child Following Accidental Alphachloralose Ingestion: A Case Study with In-Silico Insights

Year: 2024

Type: article

Abstract: Cardiotoxicity associated with alphachloralose is poorly understood, and its underlying mechanisms remain unclear. Only a few cases have been reported in the literature. We present the case of a 5-year-old child who experienced moderate alphachloralose poisoning following accidental ingestion. Cardiac involvement was identified through elevated troponin levels, with a favorable outcome following symptomatic treatment. The interaction between alphachloralose and cardiotoxicity was evaluated using in silico methods. Alphachloralose potentially induces cardiotoxicity through 15 key overlapping targets, including STAT3, MMP2, and CASP3, identified via database integration and correlation analysis. STAT3, MMP2, and CASP3 emerge as critical targets in alphachloralose-induced cardiotoxicity, offering potential avenues for therapeutic intervention.

Source: Journal of Nursing, Education Sciences, and Medical Practice. /$c Fatima Zohra Rezouki

DOI: 10.69998/rcwbmj13

Authors: Hasnae Hoummani, Hajar El Ammari, Mohamed Chebaibi, Sanae Achour

Institutions: Centre Hospitalier Universitaire Hassan II, Sidi Mohamed Ben Abdellah University, Instituts Supérieurs des Professions Infirmières et Techniques de Santé

Language: English

Topic: Poisoning and overdose treatments

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4406002641

FWCI:

Cites: 16

Cited by:

Related to: 10