Work

Synthesis and Characterisation of Coumarin Analogues Using Palladium Catalyst and their Free Radical Scavenging Activity

Year: 2024

Type: article

Abstract: Coumarins are naturally and synthetically derived compounds containing oxygen. In this work, coumarin analogues were synthesised by Suzuki cross-coupling reaction using boronic acid in the presence of a palladium catalyst with a base. The synthesised compounds were screened for free radical scavenging activity by the DPPH method. The synthesised compound Ethyl 6-(4-fluorophenyl)-8-formyl-2-oxo-2H-chromene-3-carboxylate showed a better inhibition percentage than ethyl 6-(3,5-dimethylphenyl)-8-formyl-2-oxo-2H-chromene-3-carboxylate. The compound Ethyl 6-(4-fluorophenyl)-8-formyl-2-oxo-2H-chromene-3-carboxylate showed 80% inhibition while Ethyl 6-(3,5-dimethylphenyl)-8-formyl-2-oxo-2H-chromene-3-carboxylate showed 75% inhibition.

Source: Journal of Mines Metals and Fuels

DOI: 10.18311/jmmf/2023/47289

Authors: B. V. Nagesh, Jepangsur Aier, Basappa C. Yallur, Vinayak M. Adimule, Maya Pai, Raviraj Kusnoor, Sheetal R. Batakurki

Institutions: Ramaiah Institute of Technology, M S Ramaiah University of Applied Sciences, R.V. College of Engineering

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

OpenAlex ID: W4406038381

FWCI:

Cites: 19

Cited by:

Related to: 10