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Amyotrophic Lateral Sclerosis and Myasthenia Gravis: Comorbidities and Differential Diagnosis

Year: 2024

Type: article

Abstract: Amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG) are both characterized by primarily motor deficit, and their differential diagnosis may be sometimes challenging. We present a case report of a patient with late-onset ALS, which was initially misdiagnosed for anti-acetylcholine (anti-AChR) antibody-positive MG. In some cases, ALS has been thought to be triggered by MG. In the presented case report, elevated anti-AChR antibody titers (positive anti-AchR Ab) had no clinical significance and possibly indicated an immune response to structural changes in the postsynaptic membrane of the neuromuscular synapse in the ALS patient.

Source: Annals of Clinical and Experimental Neurology

DOI: 10.17816/acen.1098

Authors: Ekaterina V. Pervushina, Mansur A. Kutlubaev, Rim V. Magzhanov, Maksim V. Brazhnikov, Svetlana M. Farrakhova

Institutions: Bashkir State Medical University, Republican Clinical Hospital named after G.G. Kuvatova

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4406045744

FWCI:

Cites: 16

Cited by:

Related to: 10