The role of inflammatory cytokines in the pathogenesis of obesity: a crucial area of study in the field of inflammation and obesity
Year: 2024
Type: article
Abstract: Obesity is a complex condition characterized by an excessive build-up of fat that poses serious health hazards. Type 2 diabetes, insulin resistance, and cardiovascular disease are metabolic diseases that are significantly influenced by chronic low-grade inflammation. Tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) are examples of inflammatory cytokines that are important in this inflammatory response. Obese people's adipose tissue is the primary source of TNF-α, which phosphorylates serine residues on insulin receptor substrate-1 (IRS-1) to interfere with the insulin signaling pathway. This prevents IRS-1 from activating downstream signaling molecules that are crucial for the uptake of glucose. Furthermore, TNF-α influences lipid metabolism by inducing lipolysis, which generates free fatty acids that worsen inflammation and insulin resistance. Adipose tissue also secretes IL-6, another pro-inflammatory cytokine that influences the liver's ability to produce glucose and raises insulin resistance. To lessen their detrimental effects on insulin sensitivity and general metabolic health, tailored treatment approaches, including TNF-α, IL-6, and IL-1β in the metabolic inflammation of obesity, must be developed. This will require a clearer understanding of their complex functions. This literature review aims to investigate the function of inflammatory cytokines in the pathophysiology of obesity in greater detail, with the ultimate goal of contributing to a more comprehensive understanding of these complex functions.
Source: Bali Medical Journal
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4406046633