Work

Study of the irisin hormone on metabolism and mitochondrial dynamics in experimental models of Alzheimer’s disease

Year: 2024

Type: article

Abstract: BACKGROUND: Age-related decrease glucose utilization, coupled with insulin resistance, are key features of AD, resulting in reduced glucose utilization/catabolism and oxidative stress generation. Irisin, an exercise-induced hormone promoting mitochondrial biogenesis in adipocytes via PGC-1α, stimulates thermogenic pathways, increases energy expenditure and induces browning of adipose tissue. Further, irisin expression was shown to trigger neuroprotection in AD models. METHOD: Here, we assessed whether irisin could prevent potential metabolic deficits induced by soluble Aβ oligomers (AβOs) in hippocampal slices and in C57BL/6 mice. RESULT: Our results indicate that irisin produced only subtle changes in the metabolic profile without clearly altering the protein content associated with mitochondrial dynamics in the AβOs-exposed hippocampus. CONCLUSION: Our data suggest that other mechanisms may possibly contribute to the neuroprotective effects of irisin in AD models.

Source: Alzheimer s & Dementia

DOI: 10.1002/alz.091085

Authors: Ariene Soares Fonseca, Mariana Gomes Chauvet, Sergio T Ferreira, Mychael V Lourenco

Institution: Universidade Federal do Rio de Janeiro

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,000