Work

A novel coumarin derivative treatment ameliorates neuroinflammation and cognitive functions in the ICV‐STZ‐induced rat model of Alzheimer’s disease

Year: 2024

Type: article

Abstract: BACKGROUND: Neuroinflammation has gained substantial attention for its involvement in the progression of Alzheimer's disease (AD). METHOD: Recently, it was discovered that platelets, which make up 90% of the circulatory Aβ, encourage the development of AD. Therefore, we hypothesized to use a novel coumarin derivative PS21HKR, which is believed to possess anti-platelet and anti-inflammatory properties for the treatment of AD. We investigated the effects of PS21HKR on STZ induced cognitive decline and neuroinflammation. Intra-cerebroventricular streptozotocin (ICV-STZ) (3mg/Kg) induced Wistar rat models of AD were used in the study. Rats were divided into 3 groups including sham, STZ and PS21HKR group. RESULT: Behavioural studies revealed that PS21HKR mitigates the cognitive deficit associated with STZ. Anti-platelet effect of PS21HKR was confirmed by tail vein bleeding assay. Further, in-vitro studies were performed on BV2 cells including the MTT assay and determination of expression of inflammatory markers. The results suggested that PS21HKR potentially regulated the expression of pro- and anti-inflammatory cytokines. CONCLUSION: Therefore, findings of this study indicate that PS21HKR has a potent neuroprotective effect by virtue of its anti-platelet and anti-inflammatory activity.

Source: Alzheimer s & Dementia

DOI: 10.1002/alz.090252

Author: PRAJJWAL SHARMA

Institution: Central University of Punjab

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,000