Evaluating the therapeutic potential of cannabis in Parkinson's Disease: An overview of the latest knowledge
Year: 2024
Type: article
Abstract: The progressive brain damage associated with Parkinson's disease (PD) develops over an extended duration.This disease is characterized by motor symptoms, particularly bradykinesia, stiffness, and dystonia.There are also non-motor manifestations such as pain, anxiety, and sleep disturbances.Levodopa and other common medications help relieve motor symptoms but are less effective at delaying the progression of the disease.This study reviews possible medical uses of cannabis for Parkinson's disease treatment.The key aspects to consider are its functionality and its advantages and drawbacks.Cannabidiol (CBD) and Δ9tetrahydrocannabinol (THC), among other plant-based compounds of cannabis, modulate the endocannabinoid system.Evidence suggests that cannabinoids may reduce neuroinflammation and oxidative stress, two processes that lead to neuronal damage.In clinical studies, both motor and non-motor symptoms improve with cannabis.It turns out that this method of treatment is an effective solution among people suffering especially from rigidity, tremors, anxiety, and sleep disturbances.However, the use of cannabis can result in drawbacks, including psychiatric effects and addiction.
Source: Medical Science
Authors: Sara Hassan, Szymon Bienia, Aisha Hassan, Kamil Hassan, Klaudia Konieczna, Wafa Al-Batool, Izabela Zarecka, Jakub Leicht, Aleksandra Kossakowska, Paweł Godlewski
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4406077371