Evaluation of Self Nanoemulsifying Drug Delivery System from Qusthul Hindi (Saussurea lappa) Extract: In vitro Release and Absorption Assessment
Year: 2024
Type: article
Abstract: This study aimed to determine the release and absorption flux values of qusthul Hindi (Saussurea lappa) self nanoemulsifying drug delivery system using the template formula for the optimal D-optimal design approach. The method is emulsification. The in vitro release test used the dialysis bag method. The absorption test was carried out through the intestinal membrane using the Crane and Wilson tube method. The levels released and absorbed were measured using a UV-Vis Spectrophotometer. The results showed that in vitro release and absorption values in SNEDDS were higher than the qusthul Hindi (Saussurea lappa) extract solution in both artificial intestinal fluid media at pH 6.8 ± 0.05 and artificial gastric fluid at pH 1.2 ± 0.05. The analysis found a significant difference in flux for both release (p=0.02) and absorption (p=0.01). The SNEDDS formula provided in vitro release flux results that were 4.20 times higher in AGF media and 5.62 times higher in AIF media compared to the extract solution. In vitroabsorption results also indicated a 4.02 times increase in AGF media and 3.32 times higher in AIF compared to the extract solution. The selected formulas using miglyol 812, Tween 80, and Polyethylenflycol 400 components at concentrations of 2.13%, 5.81%, and 2.06% can be used for SNEDDS formulations of qusthul Hindi (Saussurea lappa). These formulations showed superior in vitro release and absorption results compared to the extract solution in both AIF media at pH 6.8 ± 0.05 and AGF media at pH 1.2 ± 0.05.
DOI: 10.13005/bpj/3028
Institution: Universitas Islam Negeri Maulana Malik Ibrahim
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4406083453