Year: 2025
Type: article
Abstract: Lipid-like nanoparticles (LLNPs) have been shown to be an effective encapsulation and delivery tool for therapeutic molecules. While the preclinical development of lipid nanoparticle formulations has been of paramount importance, next-generation LLNPs present an opportunity of enhanced biocompatibility. With the change in amido functionality as part of the core backbone, our target, carbamate functionality within the LLNP core scaffold, was realized upon reaction of a protected amino alcohol onto the isocyanate generated in situ via a Curtius rearrangement. The single-step assembly of carbamate functionality starting from cyclohexane carboxylic acid in the presence of diphenylphosphoryl azide (DPPA) exceeds the metrics set forth for the rapid installment and enhanced biodegradability of next-generation lipid-like nanoparticles.
Source: Molbank
DOI: 10.3390/m1947
Authors: Bailey N. Baxter, Mary Helene Marmande, Alyssa M. Albers, Manisha R. Gangasani, Hao N. Le, Omar E. Molokhia, Juanita Monteiro-Pai, Kyndall V. Ransom, David C. Forbes
Institution: University of South Alabama
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $603
Funder: University of South Alabama
OpenAlex ID: W4406099730