Work

Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits

Year: 2024

Type: article

Abstract: Purpose: To evaluate the ultrastructure of the choriocapillaris, retina and optic nerve (ON) in citicoline-treated versus non-treated rabbits at the late time point after inducing non-infectious anterior and intermediate uveitis.Methods: The ultrastructure of the rabbit choriocapillaris, retina and ON was evaluated at day 55 after the initiation of uveitis.Results: Experimentally induced uveitis caused neurodegenerative changes in the retina and ON. Neuroprotective treatment activated intracellular compensative processes resulted in reduced signs of hydropic degeneration and normalized cell ultrastructure, and contributed to the activation of metabolism in ON glial cells and axoplasm.Conclusion: Neuroprotective treatment for non-infectious anterior and intermediate uveitis resulted in a reduction in neurodegenerative changes in the retina and ON.

Source: Oftalmologicheskii Zhurnal

DOI: 10.31288/oftalmolzh202465459

Authors: V. Ulianov, I. Horianova, N. Molchaniuk

Institutions: National University Odesa Law Academy, Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine

Language: English

Topic: Ocular Diseases and Behçet’s Syndrome

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4406103137

FWCI:

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