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The relationship between long noncoding RNA H19 genotypes and the clinical features of diabetic retinopathy

Year: 2025

Type: article

Abstract: Diabetic retinopathy (DR) is a microvascular complication of diabetes characterized by an inflammatory response.The H19 gene plays a role in regulating inflammation and is associated with chronic systemic inflammation.This study aims to investigate the potential correlation between single-nucleotide polymorphisms (SNPs) in the H19 gene and the development of DR.Five loci of H19 SNPs-rs3024270 (C/G), rs2839698 (C/T), rs3741219 (A/G), rs2107425 (C/T), and rs217727 (C/T)-were genotyped using TaqMan allelic discrimination in 454 individuals without DR and 272 DR participants.The results indicate that the H19 SNP rs3741219 AG (p = 0.030) and AG+GG (p = 0.037) alleles are significantly associated with an increased risk of developing DR in individuals with diabetes onset before the age of 45.Additionally, diabetic individuals with the H19 SNP rs3741219 AG+GG genotype also showed significantly higher serum creatinine (p = 0.034), lower glomerular filtration rate (GFR) (p = 0.013), higher total cholesterol/HDL ratio (p = 0.031), and higher triglycerides (p = 0.012).In an age-based subgroup analysis, GFR was significantly lower in diabetic patients with an onset of diabetes before 45 years and with the H19 SNP rs3741219 AG+GG genotype (p = 0.012).In conclusion, the presence of the H19 SNP rs3741219 variant is associated with a higher risk of DR in individuals with early-onset diabetes, and the relationship between the rs3741219 variant and decreased GFR is particularly pronounced in this population.

Source: International Journal of Medical Sciences

DOI: 10.7150/ijms.105022

Authors: Michael Chia-Yen Chou, Hsiang-Wen Chien, Chia-Yi Lee, Shun-Fa Yang, Hung-Yu Lin