Work

Transcriptomic Profiling of Growth Stage-Specific Gene Expression in Hanwoo Liver

Year: 2024

Type: article

Abstract: This study investigates gene expression changes in Hanwoo liver tissue across early growth stages to understand the molecular mechanisms underlying liver development and immune functions. Using weighted gene co-expression network analysis (WGCNA), we analyzed liver samples from 10 days (n = 3), 2 months (n = 10), 6 months (n = 6), and 10 months (n = 10) Hanwoo calves to identify growth stage-specific gene modules. We identified significant gene expression patterns related to immune responses, metabolic processes, and extracellular matrix organization, particularly at critical developmental stages. The findings suggest a dynamic shift in liver functions, particularly immune modulation in early months, as highlighted by the involvement of immune-related hub gene DOCK2 and enhanced metabolic activity as calves mature. These results contribute to understanding liver-specific development and may support strategies for improving growth and health in Hanwoo cattle.

Source: Journal of Animal Breeding and Genomics

DOI: 10.12972/jabng.20240412

Authors: Taejoon Jeong, Woncheoul Park, Sunsik Jang, Dajeong Lim

Institutions: Chungnam National University, Rural Development Administration, National Institute of Animal Science

Language: English

Topic: Genetic and phenotypic traits in livestock

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Zero hunger

Open Access status: hybrid

Funder: Chungnam National University