Year: 2024
Type: article
Abstract: Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) belongs to the CMGC group of kinases that are named after cyclin-dependent kinases (CDKs), mitogen-activated protein kinases (MAPKs), glycogen synthase kinases (GSKs), and CDC-like kinases (CLKs). DYRK-related kinases comprise a novel subfamily of protein kinases with unique structural, biochemical, and enzymatic features. In humans, DYRKs phosphorylate a set of proteins and play a critical role in apoptosis, DNA damage repair, cell proliferation, survival, and development. Dysregulation of DYRK protein kinases has been associated with cancer biology. In recent years, several studies have reported some kinase inhibitors affecting cancer development and progression, making them potential therapeutic drugs. However, challenges remain in understanding the molecular mechanisms and roles of each member of DYRK family in cancer initiation and progression. In this review, we will highlight the importance of DYRK kinases in cancer biology.
Source: Serican Journal of Medicine
Authors: Sayed A. Moududee, Zongbing You
Institution: Tulane University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Award: G1447144398
OpenAlex ID: W4406144639