Work

Molecular docking, ADMET, synthesis and anti-proliferative of novel derivatives of benzothiazine against lung cancer cell line

Year: 2025

Type: article

Abstract: One of the most intriguing epigenetic targets for medication therapy is epidermal growth factor receptor tyrosine kinase (EGFR-TK). Overexpression of EGFR-TK is seen in many illnesses, including cancers. In the cnew EGFR-TK inhibitors were designed with the same consisting of erlotinib (approved anticancer drug) with longer linker and substituted hydrophobic moiety using Ligand Designer from Glide (Schrodinger LLC). By experimenting with different amide and Schiff base residues, the linker was o

Source: Journal Of Advanced Pharmacy Education And Research

DOI: 10.51847/zs9rtyyias

Authors: Haider Jabbar Al-Karagully, Mohammed Kamil Hadi

Institutions: Ministry of Health, University of Baghdad

Language: English

Topic: Phenothiazines and Benzothiazines Synthesis and Activities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: University of Baghdad