Work

Transspinal stimulation downregulates flexion reflex pathways during walking in healthy humans

Year: 2025

Type: article

Abstract: Transspinal stimulation over the thoracolumbar region above and below paresthesia intensities at 15, 30, and 50 Hz produces a generalized depression of the tibialis anterior flexion reflex during walking in healthy participants. This finding supports strong actions of transspinal stimulation on spinal neuronal networks engaged in walking. This finding may be helpful for recovery of walking after spinal cord injury in humans because suppression of exaggerated flexion reflexes enables smooth stance-to-swing transition and foot clearance.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00453.2024

Authors: Maria Knikou, Abdullah M. Sayed Ahmad

Institutions: The Graduate Center, CUNY, College of Staten Island, City University of New York

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: New York State Department of Health - Wadsworth Center