Work

Manipulating metal–ligand binding in allosteric coordination complexes through ring strain

Year: 2025

Type: article

Abstract: The weak-link approach (WLA) to organometallic complexes offers a powerful method to create allosteric shape-shifting coordination complexes. However, chemically tuning the metal-ligand interactions entails challenging syntheses. This study explores the influence of ring strain on the lability of the platinum-sulfur interaction within WLA complexes, providing a simpler alternative to chemical modifications. We study the relationship of ring size, and subsequent reactivity within 4- to 8-membered WLA cyclic Pt coordination complexes through solution and solid-state studies. These results show that strain can direct the energetic preference for the desired allosteric states and therefore, the choice of small molecule effectors required to facilitate such interconversions.

Source: Chemical Communications

Authors: Yiming Hu, Fiona Yihan Wang, Yi Xie, Benjamin D. Coleman, Charlotte L. Stern, Chad A. Mirkin

Institutions: Northwestern University, International Institute for Nanotechnology

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: National Science Foundation, Northwestern University, Sherman Fairchild Foundation, Air Force Office of Scientific Research

Awards: Protein Crystallization Programmed with DNA, Allosterically Regulated Supramolecular Capsules and Receptors Assembled via the WLA, G3875120805

OpenAlex ID: W4406171322

FWCI: 0.584

Cites: 36

Cited by: 2

Related to: 10