Work

Attenuation of alginate lyase by chlorhexidine in the alginate pathway of Pseudomonas aeruginosa biofilm formation

Year: 2025

Type: article

Abstract: Ventilator-associated pneumonia (VAP) caused by Pseudomonas aeruginosa poses a significant clinical challenge due to the pathogen's robust biofilm formation and resistance mechanisms. Chlorhexidine (CHX), a commonly used antiseptic, has shown potential in biofilm inhibition, though its exact mechanism remains unclear. Our previous work focusing on quorum sensing associated proteins identified strong CHX binding to PslG, a key protein in the Psl pathway. However, the potential for CHX interac

Source: Journal Of Advanced Pharmacy Education And Research

DOI: 10.51847/lyqj0dblmr

Authors: Mohammad Subkhan, Sukardiman Sukardiman, Isnin Anang Marhana, Laily Irfana

Institution: Universitas Airlangga

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4406174029