Work

Personalized Immune Compatibility Likelihood for More Equitable HLA Matching Opportunities

Year: 2025

Type: article

Abstract: Background: Though HLA matching increases graft survival in deceased donor kidney transplant (DDKT) recipients, it has been found to amplify racial disparities due to differences in the HLA make up of donor and candidate populations. Thus, HLA matching priority has been reduced several times in the allocation system. We developed a novel metric of personalized immune compatibility likelihood (PICL) that measures each candidate’s likelihood of having donors in various antigen level risk categories and propose allocation priority adjustment based on PICL to increase the rate of well-matched DDKT without exacerbating racial disparities.

Source: American Journal of Transplantation

DOI: 10.1016/j.ajt.2024.12.187

Authors: Luckmini Liyanage, Daniyar Akizhanov, Dorry Segev, Loren Gragert, Michal Mankowski

Institutions: New York University, Tulane University

Language: English

Topic: Renal Transplantation Outcomes and Treatments

Subfield: Transplantation

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: hybrid

Estimated APC paid: $4,300