Year: 2025
Type: article
Study design: Observational Study
Abstract: Poster Sessionsfunction and allograft survival.Many institutions, however, may be over relying on pumping parameters by discarding kidneys with high resistances which may serve as viable organs in select patients.In this study, we investigated the outcomes of DDRTs to determine if high resistance kidneys should be used to increase organ utilization.Methods: We performed a retrospective analysis of 235 DDRTs conducted at Hackensack University Medical Center between 12/23/20-1/16/24 that used HMP preoperatively.Renal allografts were assigned to cohorts by their resistance (0.00-0.19, 0.20-0.29,0.30-0.39,0.4-0.49,>0.5).Estimated glomerular fi ltration rate (eGFR) was compared at timepoints up to 12 months post transplant.A general linear model was used regressing fi nal resistance categories on eGFR by time.Delayed graft function (DGF) was regressed on fi nal resistance using logistic regression.Signifi cance was set at the 0.05 level.Results: Higher fi nal resistance values were associated with signifi cantly lower eGFR across all timepoints (beta = -99, 95%CI [-13.6,-6.4], p<0.001) as well as signifi cantly increased odds of DGF (OR = 5.6, 95%CI [3.2, 10.2, p<0.001).Among functioning kidneys at 1 year, mean eGFR was > 40 across all resistance groups (Table 1).Conclusions: High resistance kidneys are correlated with reduced function at 1 year and higher rates of DGF.However, despite the reduced function, these select kidneys can be used safely to expand the donor pool.The inverse relationship between renal resistance and allograft function should be used to identify the proper recipient for the donor risk.
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
OpenAlex ID: W4406187050