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Protocol-Driven Insulin Regimen Improves Parenteral Nutrition-Induced Hyperglycemia and Provides Trend Toward Meeting Dextrose Calorie Goals While Posing a Low Hypoglycemic Risk

Year: 2025

Type: article

Abstract: Parenteral nutrition (PN)-induced hyperglycemia is a well-documented obstacle among hospitalized patients. We retrospectively investigated the effects of a protocol-driven insulin regimen (IR) compared with provider discretion (PD) insulin management for PN-induced hyperglycemic incidents. There were no statistical differences for duration to euglycemia, proportion meeting PN dextrose goal (PN goal), or hypoglycemia; however, a trend of achieving PN goal was noted at 63.64% (IR) and 34.62% (PD) and the incidence of euglycemia was higher with IR (90.91%) compared with PD methods (42.31%, P = .01). An IR may improve PN-induced hyperglycemia with a trend of achieving PN goals compared with PD methods.

Source: Topics in Clinical Nutrition

DOI: 10.1097/tin.0000000000000370

Authors: Kimberly Cephas, Saide Nakazi, Hope Kincaid, Sharmila Koshy, Robert McCauley, Gretchen Perilli

Institutions: Lehigh Valley Health Network, Lehigh Valley Hospital, Crouse Hospital

Language: English

Topic: Hyperglycemia and glycemic control in critically ill and hospitalized patients

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4406206574

FWCI:

Cites: 16

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Related to: 10