Year: 2025
Type: preprint
Abstract: Preeclampsia is a “placenta-derived disorder” characterized disease, which remains a major unaddressed public health problem. The differentiation and development of cytotrophoblasts and extravillous trophoblasts are two crucial processes, which are tightly regulated. And any abnormal regulation can lead to the occurrence of pregnancy-related diseases such as preeclampsia. In this article, we performed Spatial transcriptomics on tissues of PE and Normal, and found a large amount of extravillous trophoblasts (EVTs) were accumulated in the cluster 8 (cytotrophoblast shell) of PE_decidua, and Trajectory analysis revealed KRT8 was over-expressed in the cytotrophoblast shell of PE_decidua. The accumulation of EVTs caused by the increase of KRT8 promotes the development of preeclampsia.
Source: medRxiv
Authors: Miaomiao Chen, Xiaohong Yang, Xiangyi Chen, Hen Yin, Junbo Wu, Jing Peng, Menghan Sha, Chunyan Liu, Qianwen Dai, Kai Zhao, Yun Zhao
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4406212195