Work

Potential effects of sweet almond oil in the treatment of Alzheimer’s disease targeting BDNF and TrkB: An In Silico Molecular docking and ADMET Evaluation Study

Year: 2024

Type: article

Abstract: Background Alzheimer’s disease (AD) is the most prevalent cause of dementia accounting for an estimated 60% to 80% of cases. Despite advances in the research field, developing truly effective therapies for AD symptoms remains a major challenge. Sweet almond contain nutrients that have the potential of combating age‐related brain dysfunction, by improving learning, memory and neurocognitive performance. Neurotrophins are molecules that support neuroplasticity and are capable of promoting neuronal survival, controlling cell proliferation and neuronal differentiation. Brain‐derived neurotrophic factor (BDNF) is the most abundant neurotrophic factor that signals through the tropomycin receptor kinase B (TrkB). It plays a critical role in learning and memory by promoting survival of neurons and modulating synaptic connectivity. Loss of BDNF/TrkB signaling has been reported to play a role in AD, suggesting a pathologic involvement. Method 42 compounds in sweet almond oil were identified using GC‐MS analysis. The 2D structures of all the compounds were retrieved from PubChem database and the 3D structures of BDNF (PDB: 1B8M) and TrkB (PDB: 1WWB) were downloaded from RCSB database. BDNF and TrkB were prepared using PyMOL software and ligand preparation/docking were carried out using PyRx software. ADMET evaluation of the compounds was performed using ADMETlab 2.0 server. Result 12 compounds were found to have a higher binding affinity than Memantine, a drug that was reported to upregulate BDNF/TrkB expression in the brain. The docking results revealed that CID‐2116, CID‐6421311, CID‐5357430, CID‐541960, CID‐543355, CID‐37153, CID‐67513, CID‐543450, CID‐31039, and CID‐35698 have binding affinity of ‐11.2 kcal/mol, ‐7.4 kcal/mol, ‐6.8 kcal/mol, ‐6.6 kcal/mol, ‐6.1 kcal/mol, ‐6.0 kcal/mol, ‐6.0 kcal/mol, ‐5.8 kcal/mol, ‐5.7 kcal/mol, ‐5.7 kcal/mol respectively against BDNF that exceeded Memantine (‐5.6 kcal/mol). The result also revealed that CID‐2116, CID‐141010, CID‐31039, and CID‐549641 have binding affinity of ‐9.3 kcal/mol, ‐6.6 kcal/mol, ‐6.1 kcal/mol, and ‐6.0 kcal/mol respectively against TrkB receptor that exceeded Memantine (‐5.7 kcal/mol). All of these compound showed positive BBB penetration, 0 alert on acute toxicity rule and obeying Lipinski’s rule of five parameters. Conclusion The results of this study revealed that some compounds of sweet almond oil have potential therapeutic activity against BDNF/TrkB expression with low systematic toxicity.

Source: Alzheimer s & Dementia

DOI: 10.1002/alz.088768

Authors: Rahmat Hassan Salis, Uduak Emmanuel Umana, Adamu Abubakar Sadeeq

Institution: Ahmadu Bello University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,000