Advancements in graft-versus-host disease prevention in hematopoietic stem cell transplantation
Year: 2025
Type: article
Abstract: : Graft-versus-host disease (GVHD) remains a critical obstacle in the success of allogeneic hematopoietic stem cell transplantation (HSCT), adversely affecting patient survival and posttransplant quality of life. Recent advancements in GVHD prophylaxis emphasize achieving a delicate equilibrium between effective immunosuppression and preservation of the graft-versus-tumor (GVT) effect. This article synthesizes cutting-edge developments, including immune modulation strategies such as regulatory T-cell expansion and cytokine blockade, novel pharmacological approaches like Janus kinase inhibitors and posttransplant cyclophosphamide, and cellular therapies leveraging mesenchymal stromal cells and ex vivo-expanded regulatory T cells. Furthermore, the advent of biomarkers such as ST2 and microRNA signatures has enabled early risk stratification, fostering personalized, risk-adapted prophylactic strategies. By integrating these innovations, HSCT outcomes can be significantly improved, offering enhanced safety, reduced GVHD incidence, and optimized long-term patient care.
Source: Iraqi Journal of Hematology
Institutions: Siksha O Anusandhan University, Institute of Medical Sciences and Sum Hospital, Saveetha University, University of Cyberjaya, Manav Rachna International Institute of Research and Studies, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune, Dr D Y Patil Dental College & Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4406224778