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Figure 4 from Preclinical Development of T Cells Engineered to Express a T-Cell Antigen Coupler Targeting Claudin 18.2–Positive Solid Tumors

Year: 2025
Type: other
Abstract: Clearance of gastric tumor spheroids by CLDN18.2-TAC T cells. A, Cytotoxicity of TAC01-CLDN18.2 against N87CLDN18.2 tumor spheroids. GFP-expressing N87CLDN18.2 spheroids aggregated with CAFs were cocultured with CLDN18.2-TAC T cells at various E:T ratios for 7 days. Left: Microscopy images of tumor spheroids (E:T = 5:1). Right: Quantitation of GFP fluorescence over time. Dotted lines denote NTD cocultures. Averages and SDs of experiments done in triplicates are shown. B, IHC analysis of spheroids cultured at E:T = 5:1 and collected on day 2. H&E, hematoxylin and eosin; NT, not treated; RFU, relative fluorescence units; VIM, vimentin.
DOI: 10.1158/2326-6066.28171923
Authors: Stacey X. Xu, Ling Wang, Philbert Ip, Ritu R. Randhawa, Tania Benatar, Suzanna L. Prosser, Prabha Lal, Alima Naim Khan, Thanyashanthi Nitya-Nootan, Gargi Thakor, Heather MacGregor, Danielle L Hayes, Andrea Vucicevic, Princy Mathew, Sadhak Sengupta, Christopher W. Helsen, Andreas G. Bader
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
OpenAlex ID: W4406227728
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