Work

Calcium calmodulin kinase IV deficiency in podocytes prevents the development of lupus nephritis

Year: 2025

Type: article

Abstract: mice exhibited reduced glomerular pathology, characterized by less mesangial cell proliferation and diminished immune complex deposition, accompanied by decreased levels of albuminuria and improved creatinine levels. CaMK4 deficiency in podocytes averted the deposition of immune complexes in the kidney. Interestingly, we found increased deposition of immune complexes in the liver. We conclude that CaMK4 expression in podocytes is central to the development of LN and its targeted deletion in podocytes prevents its development without affecting systemic autoimmunity while immune complexes appear to be re-directed from the kidney to the liver.

Source: Clinical Immunology

DOI: 10.1016/j.clim.2025.110427

Authors: Rhea Bhargava, Hao Li, Kayaho Maeda, Maria G. Tsokos, George C. Tsokos

Institutions: Tulane University, Beth Israel Deaconess Medical Center, Harvard University

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,400