Impact of gold nanoparticle size and coating on radiosensitization and generation of reactive oxygen species in cancer therapy

Year: 2025

Type: article

Abstract: production, suggesting that multiple reactive species contribute to the radiosensitization process. Clonogenic assays confirmed that PEG-capped AuNPs produced stronger radiosensitizing effects than citrate-capped AuNPs, with smaller AuNPs providing more pronounced biological effects. This study underscores the importance of conducting both chemical and biological evaluations to fully understand the radiosensitization efficacy of AuNPs.

Source: Nanoscale Advances

DOI: 10.1039/d4na00773e

Authors: E. Loscertales, R. López-Méndez, J. Mateo, L. M. Fraile, J. M. Udias, A. Espinosa, S. España

Institutions: Universidad Complutense de Madrid, Consejo Superior de Investigaciones Científicas, Instituto de Tecnologías Físicas y de la Información “Leonardo Torres Quevedo”, Madrid Institute for Advanced Studies, IMDEA Nanoscience, Spanish National Centre for Cardiovascular Research, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Instituto de Ciencia de Materiales de Madrid

Language: English

Topic: Radiation Therapy and Dosimetry

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962

Funders: Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades, Ministerio de Ciencia e Innovación, Centro Nacional de Investigaciones Cardiovasculares, Instituto de Salud Carlos III, Agencia Estatal de Investigación

OpenAlex ID: W4406230510