Work

Highly Selective AIEgen‐Based “Turn On” Fluorescent Imaging for Inflammation Detection

Year: 2025

Type: article

Abstract: Hypochlorous acid (HClO) is released by immune cells in the immune system, and it helps the body fight off infections and inflammation by killing bacteria, viruses, and other pathogens. However, tissue damage or apoptosis may also be induced by excess HClO. On this basis, we designed the probe TPE-NS by choosing tetraphenylethylene (TPE) as the luminescent unit and dimethylthiocarbamoyl chloride as the recognition site. By Gaussian's transition state calculations, HClO will cut off the photoinduced electron transfer (PET) effect of TPE-NS by hydrolysis reaction, thus emitting strong fluorescence. TPE-NS has rapid recognition and excellent specificity for HClO, and the limit of detection is 7.27 μM. Finally, TPE-NS was successfully used for the visualization of endogenous and exogenous HClO in cell experiments.

Source: Luminescence

DOI: 10.1002/bio.70075

Authors: Cong Shao, Xiaoxuan Wang, Jingying Dai, Honglian Dai

Institutions: Wuhan University of Technology, State Key Laboratory of Advanced Technology For Materials Synthesis and Processing, National University of Singapore

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, China Scholarship Council, National Key Research and Development Program of China, Basic and Applied Basic Research Foundation of Guangdong Province