Work

Regio‐ and Enantioselective Rhodium‐Catalyzed Allylic Arylation of Racemic Allylic Carbonates with Arylboronic Acids

Year: 2025

Type: article

Abstract: Rhodium-catalyzed regio- and enantioselective allylic arylation of racemic alkyl- and aryl- substituted allylic carbonates with arylboronic acids using commercially available BIBOP ligand is reported. This reaction proceeds at room temperature without base or other additive to deliver allylic arylation products in excellent yields, regio- and enantioselectivity (up to 95 % yield, >20 : 1 b/l, >99 % ee). Rh/BIBOP is disclosed as an efficient catalytic system for allylic substitution reaction.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202421596

Authors: Hu‐Chong Wang, Wen‐Jie Shen, Shu‐Li You

Institutions: Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, State Key Laboratory of Organometallic Chemistry

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Ministry of Science and Technology of the People's Republic of China

Awards: G1188701664, G3043336389, G387334713, G431006685