Work

Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization

Year: 2025

Type: article

Abstract: Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-induced activation of macrophage/microglial cells, retinal inflammation, and pathological RNV are mediated by increases in cholesterol ester (CE) formation due to activation of the acyl-CoA: Cholesterol Acyltransferase 1/Sterol O-Acyltransferase 1 (ACAT1/SOAT1) enzyme.

Source: npj Metabolic Health and Disease

DOI: 10.1038/s44324-024-00046-x

Authors: Syed A. H. Zaidi, Ruth B. Caldwell, Modesto A. Rojas

Institution: Augusta University

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590