Work

Untangling a case of dapsone-induced acute liver injury

Year: 2025

Type: article

Abstract: Dapsone hypersensitivity syndrome, although rare, may manifest with fever, rash, and multi-organ failure, mimicking other common diseases. This case study involves a 9-year-old female patient presenting with fever and acute liver injury, in which the intake of dapsone was not revealed until much later. We discuss how the diagnosis was made and the successful outcome following prompt treatment. A high index of suspicion and vigilant history-taking, along with a detailed past treatment history, can provide early clues in reaching a diagnosis. Early intervention with systemic corticosteroids improves the outcome of dapsone hypersensitivity syndrome and can prevent mortality.

Source: Journal of Family Medicine and Primary Care

DOI: 10.4103/jfmpc.jfmpc_885_24

Authors: V Meghana, Divya Ravindran, Umapathy Pasupathy

Institution: Sri Ramachandra Institute of Higher Education and Research

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $450