A New Non-Cyanogenic Cyanoglycoside with Promising α-Glycosidase Inhibitory Activity from the Roots of Cordia trichotoma
Year: 2025
Type: article
Abstract: Three undescribed non-cyanogenic cyanoglycosides, designated as trichotomoside A (1), B (2), and C (3) along with three known ones (4-6) were isolated from the roots of Cordia trichotoma. In addition, miscellaneous compounds such as acid (1’R,3’S,5’R,8’S,2Z,4E)-dihydrophaseic 3’-O-β-D-glycopyranoside (7), N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)- 3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran5-yl]acryloylglycine (8), syringaldehyde (9), scoparone (10), 12,16-epoxyglobiferin (11), α-cadinol (12), trichotomol (13), and 1-(3’-methoxypropanoyl)-2,4,5-trimethoxybenzene (14) were also isolated. The structures of all compounds were elucidated by an extensive analysis of spectroscopic data (infrared (IR), nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HRESIMS)). The non-cyanogenic cyanoglycosides (1-6) were screened for their α-glucosidase inhibitory activities. None of the compounds exhibited antioxidant or xanthine oxidase activity. Compound 3 exhibited considerable inhibitory ability on α-glucosidase, showing a halfmaximal inhibitory concentration (IC50) = 646 ± 69 µmol L-1 close to the standard acarbose (IC50 = 521 ± 23 µmol L-1), demonstrating its promising antidiabetic action.
Authors: Késya A. D. Rocha, Francisca R. S. Lopes, Francisco C. L. Pinto, Francisco M. G. N. Pinheiro, Samuel P. D. Marques, Maria Teresa S. Trevisan, Edilberto R. Silveira, Otília D. L. Pessoa, Gilvandete M. P. Santiago
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $275
OpenAlex ID: W4406305620