Year: 2024
Type: article
Abstract: β blockers are widely used to treat cardiovascular diseases such as hypertension, coronary artery disease, and heart failure because they inhibit β adrenergic receptors. These drugs reduce heart rate, myocardial contractility, and oxygen demand, which is essential for managing a variety of heart conditions. Despite their therapeutic benefits, recent studies have highlighted their limitations in diagnostic imaging, particularly in myocardial perfusion imaging (MPI), where they may reduce sensitivity by altering blood flow patterns. Current research has made significant progress in understanding the pharmacological effects of β blockers, including their effects on heart rate, blood pressure, and myocardial function. However, optimization of use remains challenging, especially in critical care settings and diagnostic procedures. It is important to note that β blockers may affect the accuracy of stress testing, leading to misdiagnosis of ischemic areas on imaging. This study provides a comprehensive analysis of the mechanism of action of β blockers, their clinical applications, and the challenges they pose in diagnostic imaging. The results suggest that while β blockers are effective in reducing cardiovascular mortality, their impact on imaging requires careful management. Temporary discontinuation prior to stress testing may improve diagnostic outcomes, but this approach must be weighed against potential risks. Future research should focus on developing advanced imaging protocols to alleviate diagnostic limitations and explore the potential of novel β blockers that combine β and alphablocking properties. These advancements may improve the efficacy of β blockers while minimizing adverse effects, thereby providing better patient outcomes.
DOI: 10.62051/hw2rbb65
Author: Kexin Wu
Institution: Hebei University of Engineering
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4406359653