To control the para-Hydroxybenzoic Acid during the synthesis of Sodium Methyl Paraben Preservative
Year: 2024
Type: article
Abstract: Sodium Methyl Paraben (SMP) is the sodium salt of Methyl Paraben. Para-Hydroxybenzoic acid is most common Degradation impurity of Sodium Methyl Paraben. There are several mechanisms involves the formation of Para-Hydroxybenzoic Acid (PHBA) as an impurity during Sodium Methyl Paraben (SMP) synthesis. Mainly Parent paraben readily undergo base-catalyzed hydrolysis of the ester bond, forming PHBA. Solvent may affect the formation of PHBA, mainly the role of Methanol.
Source: IJPAR JOURNAL
Authors: Chirag Dhamsania, Sanghadiya Divyang G
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4406421783