Year: 2024
Type: article
Abstract: Numerous investigations and analyses have revealed that chemicals released by adipose tissue are essential for maintaining metabolic homeostasis. A lack of these molecules, resulting from either excessive adiposity or malfunctioning adipocytes, can induce obesity or a variety of diseases linked to obesity. As a result, adipose tissue is regarded as an endocrine organ, and the way it affects target organs varies depending on where fat depots are located and how it functions. Understanding the secretome of adipose tissue in its entirety may offer critical new perspectives on the roles played by the body's most crucial metabolic regulator. One of the most powerful adipokines for controlling metabolism is leptin. By communicating feelings of hunger or fullness to the hypothalamus, it regulates body weight by releasing neurotransmitters that modify energy expenditure and food intake. Additionally, leptin enhances muscle fatty acid oxidation and suppresses the pathway that leads to fatty acid synthesis, which controls hepatic lipogenesis. The most prevalent adipokine that is secreted is adiponectin, it improves insulin sensitivity and partially reverses insulin resistance. In order to treat the inflammation and insulin resistance brought on by obesity, researchers are currently looking into ways to raise adiponectin levels or adiponectin receptor activity. The female sex hormone also causes fat to be stored in the buttocks, thighs and hips in women. Men are more likely to store belly fat due to sex hormone differences. When a woman reaches menopause and the percentage of estrogen produced by the ovaries decreases, fat migrates from the buttocks, hips,
Authors: Hind Khalaf, Hadeel Abdel Razaaq, Baydaa Atiyah
Institution: University of Anbar
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4406434061