Work

Interleukin-10 and interferon-gamma serum levels correlation with some liver function parameters in hepatitis C chronically infected patients

Year: 2024

Type: article

Abstract: Aims: Estimating interleukin-10 (IL-10) serum levels and interferon-gamma (INF-γ) and their correlation with hepatic biochemical parameters in chronic HCV-infected patients versus healthy controls.Methodology and results: Our study consisted of forty-four (44) patients with chronic hepatitis C aged 16-57 years plus forty (40) healthy controls aged 18-54.Samples were collected from various hospitals in Dohuk Governorate, Iraq.Biochemical liver function markers were assessed using traditional methods according to IFCC instructions.Serum concentrations of IL-10 and INF-γ levels were assessed using abcam® kits and according to the manufacturer's instructions.HCV RNA were quantified using the fully automated GeneXpert ® system.Conclusion, significance and impact of study: A significant difference in IL-10 and INF-γ serum levels between HCVinfected patients and healthy controls were detected.There were also several significant correlations between these inflammatory cytokines and liver function markers in HCV-infected individuals.

Source: Malaysian Journal of Microbiology

DOI: 10.21161/mjm.240048

Authors: Abbas, A. H., AL-Taee, H. A.

Institutions: University of Mosul, Ninevah University

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $110