An estimation of efficiency of assisted reproductive technologies is at the combined forms of infertility taking into account age of patients
Year: 2024
Type: article
Study design: Observational Study
Abstract: The objective: to learn the role of age of patients in the estimation of efficiency of assisted reproductive technologies at the combined forms of infertility.Materials and methods. By us 70 women of reproductive age, which made the followings groups, were inspected: basic (n=30), comparison (n=30) and control (n=10). Criteria of exception for a basic group and group of comparison were general: hyper- and hypogonadal гovarian insufficiency; a delete of one or both ovaries is in anamnesis; heavy degree of asthenoeratozoospermia, azoospermia only reason of infertility is a masculine factor; obesity of II–III of degree.In the complex of the conducted researches were included clinical, echographic, endocrinology, morphological, statistical and immunological methods which included determination of level of cytokines in a follicle liquid the method of the multiplexed analysis of albumens. Results. It is got by us results testify that with the increase of age of patients appropriately goes down amount of growings follicles (Rс=-0,32; р<0,05); ovaries of oocytes (Rс=-0,33; р<0,01) got during puncture, including mature (Rс=-0,31; р<0,05). It specifies on the decline of activity of processes of follicculo- and oogenesis, frequency of offensive of pregnancy with the increase of age of women. These processes are conditioned morpho-functional by the changes of ovaries for the women of senior age, by the decline of them ovarian reserve, by the increase of frequency of aneuploidy of oocytes, which can appear one of reasons of low frequency of implantation. Except for the physiology increase of frequency of elimination of primordial follicles in senior reproductive age, by factors which result in the decline of efficiency of gonadotropic stimulation of ovaries for the inspected patients, there could be concomitant gynaecological diseases (chronic salpingo-oophoritis, external genital endometriosis), carried operative interferences on the organs of the reproductive systemConclusions. The results of the conducted researches testify that to informing clinical-and-anamnestic and hormonal factors which determine the result of cycle of assisted reproductive technologies for the patients of reproductive age with the combined forms of infertility, take: age of 133127вичт р ольітчі72к7 упат р ольцвід наукових досліджень до практики | Perinatology and reproductology:from research to practiceNo3-1 Vol. 4 • 2024ISSN 2788-6190БЕЗПЛІДДЯpatient; body index mass; presence tubo-peritoneal factor of infertility; a level of free testosterone is in blood; a table of contents of progesterone is in blood on 20–22 days of menstrual cycle, and also determination in the follicle liquid of ovaries of cytokines. By us the rotined role of age of patients in the estimation of efficiency of assisted reproductive technologies.Keywords:assisted reproductive technologies, combined forms of infertility, age of patients, efficiency.
Author: Andrey Shchedrov
Institution: V. N. Karazin Kharkiv National University
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4406498660