Work

Remote ischemic preconditioning attenuates ischemia-reperfusion injury-induced reductions in vascular function through release of endogenous opioids

Year: 2025

Type: article

Abstract: Remote ischemic preconditioning (RIPC) is a cardioprotective therapy characterized by brief cycles of limb ischemia and reperfusion. We demonstrate that a single bout of arm RIPC provides protection from ischemia-reperfusion injury-induced reductions in vascular function in healthy adults. This protection was attenuated when RIPC was administered in the presence of systemic opioid-receptor blockade via intranasal naloxone. These findings suggest that endogenous opioids contribute to RIPC-induced protection of vascular function in humans.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00913.2024

Authors: Alexander J. Rosenberg, Alexander Fernandez, Ayrion W. Moody, Justin D. Sprick

Institutions: Midwestern University, University of North Texas

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: University of North Texas