A Clinical Evaluation of Kalpita Agnimanthadi Kashaya and its Comparative Study with Varunadi Kashaya and Navaka Guggulu in Sthaulya in the Purview of “Samtarpanotthanamapatarpanamausadham”
Year: 2024
Type: article
Study design: Clinical Trial
Abstract: Background: Sthaulya (~Obesity) is a prevalent lifestyle disorder in the modern era, significantly linked to unhealthy dietary habits, lack of physical activity, and stress. In Ayurveda, Sthaulya is classified under Samtarpanottha Vyadhi (~diseases caused by over-nourishment) and attributed to the imbalance of Kapha, Meda Dhatu (~fat tissue), and Agni (~digestive fire). Complications such as diabetes, hypertension, and cardiovascular diseases are commonly associated with Sthaulya. The Ayurvedic principle “Samtarpanotthanam Apatarpanam Ausadham” advocates Apatarpana (~depletion therapy) for managing over-nourishment disorders. This study aims to evaluate and compare the efficacy of Kalpita Agnimanthadi Kashaya with Varunadi Kashaya and Navaka Guggulu in the management of obesity. Method: A total of 30 subjects were randomly divided into two groups: Group A received Kalpita Agnimanthadi Kashaya, and Group B received Varunadi Kashaya with Navaka Guggulu. The clinical trial lasted for 60 days, with follow-up visits every 15 days. Parameters for evaluation included subjective symptoms (Javoparodha, Daurbalya etc.) and objective measures (body weight, BMI, waist-hip ratio). Biochemical investigations such as serum cholesterol, triglycerides, LDL, and HDL levels were recorded pre- and post-treatment. Statistical analysis was performed using appropriate tests. Results: Both groups showed significant improvement in subjective and objective parameters. Group B demonstrated slightly better efficacy in reducing waist circumference, hip circumference, and waist-hip ratio, with statistically significant differences (p<0.05) in intergroup comparisons. Biochemical parameters such as serum cholesterol and LDL levels improved notably in both groups, with HDL levels showing a significant increase in Group B. Conclusion: Both Kalpita Agnimanthadi Kashaya and Varunadi Kashaya with Navaka Guggulu were effective in managing obesity. The principle of Apatarpana (~depletion therapy), as proposed in Ayurveda, was validated by the significant reduction in clinical and biochemical parameters. Future studies with larger sample sizes are recommended to further establish these findings.
Author: Dr. Kumar Anil
Institution: National Institute of Ayurveda
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4406583045