Year: 2024
Type: article
Abstract: Osteoporosis is a chronic disease commonly associated with menopause, primarily triggered by estrogen deficiency, oxidative stress, and inflammatory processes. These factors contribute to bone density loss, increasing the risk of fractures and reduced quality of life. This study aims to investigate the potential of anthocyanins, natural compounds found in various plants, in preventing osteoporosis by mitigating oxidative stress and promoting bone health. A comprehensive literature review was conducted by searching multiple scientific databases for relevant studies on the effects of anthocyanins on bone health. The selection criteria included experimental and clinical studies focusing on the antioxidant and bone-regulating properties of anthocyanins. The findings reveal that anthocyanins possess significant antioxidant properties that help reduce oxidative stress by lowering malondialdehyde (MDA) activity and increasing superoxide dismutase (SOD) activity. Additionally, anthocyanins promote bone formation by increasing the number of osteoblasts while decreasing the number of osteoclasts in animal models of menopause-induced osteoporosis. Anthocyanins hold potential as a natural therapeutic agent for preventing osteoporosis, particularly in menopausal women. Their antioxidant and bone-regulatory effects could complement existing osteoporosis prevention strategies, offering a safer and more natural approach to maintaining bone health.
Institution: Udayana University
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4406598634