Work

Review of Drug-Drug Interactions and Anticancer Effects of Osimertinib with Herbal Medicines: Focus on Bojungikgi-tang and Hwanglyeonhaedok-tang

Year: 2024

Type: article

Abstract: Objective: To investigate the interactions and potential anticancer effects of combining osimertinib with Bojungikgi-tang (BJIKT) and Hwanglyeonhaedok-tang (HLHDT) in non-small cell lung cancer (NSCLC) treatment.Methods: A literature review was conducted to evaluate drug interaction risks and therapeutic efficacy using pharmacokinetic models.Results: BJIKT was found to enhance the immune response, while HLHDT exhibited anti-inflammatory properties, with a minimal risk of CYP3A4 inhibition. These findings suggest the potential benefits of combining these herbal formulas with osimertinib to improve its therapeutic effects and minimize side effects.Conclusion: The combination of BJIKT and HLHDT with osimertinib shows promise as a supportive treatment strategy for NSCLC. However, further in-depth clinical studies are essential to confirm safety and efficacy.

Source: The Journal of Internal Korean Medicine

DOI: 10.22246/jikm.2024.45.6.1184

Authors: Keon-jun Lee, Dong-hyeon Kim, Seong-yoon Yang, Jung-woo Chae, Hwa-seung Yoo, So-jung Park

Institutions: Pusan National University Korean Medicine Hospital, Pusan National University, Chungnam National University, Daejeon University

Language: English

Topic: Complementary and Alternative Medicine Studies

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Korea Health Industry Development Institute, Pusan National University Hospital