Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To evaluate the prognostic significance of Nestin and Ki-67 expression in Astrocytoma across different grades.METHODOLOGY: A retrospective cross-sectional analysis was conducted at the Histology Department, Basic Medical Sciences Institute, JPMC Karachi, between October 2019 and September 2022.In this study, Nestin and KI-67 immunohistochemistry expression was assessed in 60 Astrocytoma, and its expression was seen with different degrees of Astrocytoma.RESULTS: Nestin positivity was found in 86.7% of cases of Astrocytoma.The immune-reactive score for Nestin staining in different stages of Astrocytoma was shown to have a significantly significant P-value.41.7% of cases of Astrocytoma were found to have a KI-67 labeling index; all high-grade Astrocytoma had a high labeling index of Ki-67.It was demonstrated that the immune-reactive score for Ki-67 staining at various phases of Astrocytoma had a statistically significant P-value.CONCLUSION: We discovered that Nestin and Ki-67 were expressed in Astrocytoma and that the expression of both immune markers rose with tumor grade.Nestin and Ki-67 serve as a helpful marker for assessing the Astrocytoma's prognosis.These findings may be used to determine the best course of action for Astrocytoma therapy.
Authors: Prih Bashir, Noshaba Rahat, Humera Shahzad, Asma Jalbani, Farah Siraj, Zumrud Momin
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $150
OpenAlex ID: W4406629201