Synthesis, Spectroscopic Characterization, In-Vitro and Antimicrobial Activities of Some Metal (II) Complexes of 5-choloro-2-(((4,6-Dimethoxypyrimidin-2-yl) Imino) Methyl) Phenol
Year: 2024
Type: article
Abstract: The novel Schiff base ligand has been synthesized by the condensation of 5-chlorosalicylaldehyde and 2-amino-4,6-dimethoxypyrimidine. Metal complexes of the Schiff base were prepared by the reaction of the Schiff base and Iron nitrate in ethanol solution. The complexes isolated, washed and dried. The Schiff base is pale yellow, while Cu(II) and Mn(II) complexes is light yellow.The synthesized compounds have been characterized by FT-IR, 1H-NMR and UV-Vis techniques for the ligands and FT-IR, UV-Vis, all reactions monitored by TLC, molar conductivity and magnetic susceptibility measurements for the corresponding complexes.The complexe is paramagnetic. The results of the molar conductivity measurements indicated that all complexes are non-electrolytes in (DMSO). An octahedral geometry for all the complexes of. The ligands are bidentate, (L₁) through phenolic (OH) and azomethine nitrogen. The ligand and its complexes were screened for their antifungal and antibacterial activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme, Aspergllus flavus and Escherichia coli, Salmonella typhi, Staphylococcus aureus, B. subtilis. The result indicated that the complexes exhibited good antifungal and antibacterial activities.
DOI: 10.32628/ijsrch24961
Author: D. T. Sakhare
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4406664025