Year: 2024
Type: article
Abstract: Bidens pilosa, commonly known as Ottrancedi, is a medicinal plant from the ancient period. It contains polyacetylenes, flavonoids, terpenoids, phenylpropanoids, which are well known molecules present in high concentration in medicinal plants with many antibacterial, antifungal and anticancer properties. To study the detailed mode of action of phenyl-1,3,5-heptatriyne which showed promising results on human liver cancer cell line HepG-2, we performed many assays like DNA fragmentation assay, Caspase-3 assay, Cell cycle analysis and fluorescent microscopic studies. During over studies we found that the molecule causes apoptosis in cancer cells lines by expressing high amount of Caspase-3 enzyme and it arrests the cells in G2/M phase. As it is already reported that the infusion of B. pilosa L. is non-toxic for single and repeated dose also for dermal structures so the molecule phenyl-1,3,5-heptatriyne can be a good candidate for a anticancer drug in future.
DOI: 10.56782/pps.275
Author: Uzma Faridi
Institution: University of Tabuk
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
Funder: University of Tabuk
OpenAlex ID: W4406671541