Work

Polymorphism of microsomal epoxide hydrolase and glutathione-S-transferase genes as a predictor of the effectiveness of pharmacotherapy

Year: 2024

Type: article

Abstract: Pharmacogenetics is one of the dynamic and rapidly developing areas contributing to the development of personalized medicine. It is based on the determination of polymorphic variants of genes and drug tolerance, the development of side effects, as well as the clinical response to treatment. The study of polymorphisms of genes in the xenobiotic biotransformation system is one of the promising areas in the development of personalized medicine of multifactorial diseases. In this article, we presented literature data on the influence of polymorphisms in genes of the xenobiotic biotransformation system on the effectiveness of pharmacotherapy.

Source: Journal of Volgograd State Medical University

DOI: 10.19163/994-9480-2024-21-4-31-36

Authors: Izabella S. Gulian, Ekaterina V. Eliseeva, Vladimir I. Apanasevich, Grant S. Gulian

Institutions: Vladivostok State Medical University, Far Eastern Federal University

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4406673132

FWCI:

Cites: 22

Cited by:

Related to: 10