Work

Promotion or inhibition? This is a question in gene editing

Year: 2025

Type: article

Abstract: In the November 2024 issue of Nature Biotechnology, Cullot et al. reported that “Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations.”1 This work rings the bell to an old question: how do we improve precise gene editing (PGE) outcomes—through promotion (of homology-directed repair [HDR]) or inhibition (of non-homologous end joining [NHEJ]) or both?

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2025.01.014

Authors: Li-Kuang Tsai, Renzhi Han, Dongshan Yang, Y. Eugene Chen, Jifeng Zhang, Jie Xu

Institutions: University of Michigan, Michigan Medicine, Indiana University Indianapolis, Indiana University School of Medicine

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500