Work

Reprogramming of Fatty Acid Metabolism in Acute Leukemia

Year: 2025

Type: review

Abstract: Fatty acids are essential biomolecules that support several cellular processes, such as membrane structures, energy storage and production, as well as signal transduction. Accordingly, changes in fatty acid metabolism can have a significant impact on cell behavior, such as growth, survival, proliferation, differentiation, and motility. Therefore, it is not surprising that many aspects of fatty acid metabolism are frequently dysregulated in human cancer, including in highly aggressive blood cancers such as acute leukemia. The aims of this review are to summarize the aspects of fatty acid metabolism that are specifically coopted in acute leukemia as well as current preclinical strategies for targeting fatty acid metabolism in these cancers.

Source: Journal of Cellular Physiology

DOI: 10.1002/jcp.70000

Authors: Judith Sokei, Joice Kanefsky, Stephen M. Sykes

Institutions: Washington University in St. Louis, Temple University Health System

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Washington University in St. Louis, National Institutes of Health, National Cancer Institute