Endothelial dysfunction and thrombosis in polycythemia vera
Year: 2024
Type: article
Abstract: Polycythemia vera (PV) is a chronic myeloproliferative neoplasm with an increased risk of thrombotic events. Endothelial dysfunction is a pathogenetic mechanism contributing to thrombus formation in PV. The presence of the JAK2 V617F mutation is associated with an increased risk of thrombosis due to changes in endothelial homeostasis mediated by overexpression of pro-adhesive and proinflammatory agents. Cytoreductive treatment that decreases the JAK2 allele burden and inhibits the JAK/STAT signaling pathway is potentially more effective in thrombosis prevention than drugs that are less effective in the reduction of the JAK2 allele burden. This review aims to present the spectrum of endothelial dysfunction and the impact of cytoreductive treatment on the condition of endothelial cells and thrombosis risk in patients suffering from polycythemia vera.
Source: Acta Haematologica Polonica
DOI: 10.5603/ahp.102182
Authors: Weronika Marzena Lebowa, Paweł Kuczia, Patrycja Lebowa, Tomasz Sacha
Institution: Jagiellonian University
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4406683278