Work

Structure and hormonal output of the adrenal gland after experimental estrogenization of male rats.

Year: 2025

Type: article

Abstract: , with increased cell and nuclei volumes in all three adrenocortical zones (ZG, ZF, and ZR), in comparison with Orx rats. Concentrations of aldosterone in blood, as well as corticosterone in blood and adrenal tissue were increased, while circulating DHEA was decreased (with increased immunoexpression of adrenocortical CYP 17 enzyme), all in Orx+E compared with Orx animals. The wide zonal distribution of VEGF and the pronounced blood supply within the ZF of Orx+E animals acted to support the synthesis and secretion of corticosteroids. These results seem cautionary in the context of young male estrogenization, given the negative impact of high mineralocorticoids and glucocorticoids on cardiovascular function and metabolism.

Source: PubMed

DOI: 10.14670/hh-18-872

Authors: Vladimir Ajdžanović, Pavle Ćosić, Svetlana Trifunović, Branka Šošić-Jurjević, Marko Miler, Branko Filipović, Milica Manojlović-Stojanoski

Institutions: University of Belgrade, Institute for Biological Research “Siniša Stanković”

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4406735217

FWCI: 0.541

Cites: 3

Cited by: 1

Related to: 10